Commonly referred to as an ecstatic, non-inflammatory disease, Keratoconus, usually bilateral and asymmetric, is characterized by progressive steeping and thinning of the cornea. This results in irregular astigmatism which compromises vision [1,2]. Traditionally, early Keratoconus stages have been treated by prescribing a hard contact lens to obtain a regular anterior optical surface. This tendency was discontinued when contact lens intolerance in advanced stages required the use of penetrating keratoplasty (PKP) or deep anterior lamellar Keratoplasty (DALK). An alternative technique of corneal cross-linking was designed in 2003 as a treatment option for keratoconus. The cornea measured at least 400 um thickness after epithelium removal and pre-operative maximum keratometry (Kmax) measured 58D or less. As a result, no corneal transplantation was required or postponed [3].
Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003 May;135(5):620-7. doi: 10.1016/s0002-9394(02)02220-1. PMID: 12719068.
Raiskup F, Spoerl E. Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas. Am J Ophthalmol. 2011 Jul;152(1):28-32.e1. doi: 10.1016/j.ajo.2011.01.016. Epub 2011 May 6. PMID: 21529763.
Sloot F, Soeters N, van der Valk R, Tahzib NG. Effective corneal collagen crosslinking in advanced cases of progressive keratoconus. J Cataract Refract Surg. 2013 Aug;39(8):1141-5. doi: 10.1016/j.jcrs.2013.01.045. Epub 2013 May 24. PMID: 23711873.
Alio JL, Vega-Estrada A, Esperanza S, Barraquer RI, Teus MA, Murta J. Intrastromal corneal ring segments: how successful is the surgical treatment of keratoconus? Middle East Afr J Ophthalmol. 2014 Jan-Mar;21(1):3-9. doi: 10.4103/0974-9233.124076. PMID: 24669139; PMCID: PMC3959038.
Christo CG, van Rooij J, Geerards AJ, Remeijer L, Beekhuis WH. Suture-related complications following keratoplasty: a 5-year retrospective study. Cornea. 2001 Nov;20(8):816-9. doi: 10.1097/00003226-200111000-00008. PMID: 11685058.
Kelly TL, Williams KA, Coster DJ; Australian Corneal Graft Registry. Corneal transplantation for keratoconus: a registry study. Arch Ophthalmol. 2011 Jun;129(6):691-7. doi: 10.1001/archophthalmol.2011.7. Epub 2011 Feb 14. PMID: 21320951.
Tan DT, Dart JK, Holland EJ, Kinoshita S. Corneal transplantation. Lancet. 2012 May 5;379(9827):1749-61. doi: 10.1016/S0140-6736(12)60437-1. PMID: 22559901.
Lake D, Hamada S, Khan S, Daya SM. Deep anterior lamellar keratoplasty over penetrating keratoplasty for host rim thinning and ectasia. Cornea. 2009 Jun;28(5):489-92. doi: 10.1097/ICO.0b013e31818d3b3c. PMID: 19421052.
Speaker MG, Arentsen JJ, Laibson PR. Long-term survival of large diameter penetrating keratoplasties for keratoconus and pellucid marginal degeneration. Acta Ophthalmol Suppl. 1989;192:17-9. doi: 10.1111/j.1755-3768.1989.tb07089.x. PMID: 2554648.
Abou Shousha M, Perez VL, Fraga Santini Canto AP, Vaddavalli PK, Sayyad FE, Cabot F, Feuer WJ, Wang J, Yoo SH. The use of Bowman's layer vertical topographic thickness map in the diagnosis of keratoconus. Ophthalmology. 2014 May;121(5):988-93. doi: 10.1016/j.ophtha.2013.11.034. Epub 2014 Jan 24. PMID: 24468653; PMCID: PMC4011960.
van Dijk K, Parker J, Tong CM, Ham L, Lie JT, Groeneveld-van Beek EA, Melles GR. Midstromal isolated Bowman layer graft for reduction of advanced keratoconus: a technique to postpone penetrating or deep anterior lamellar keratoplasty. JAMA Ophthalmol. 2014 Apr 1;132(4):495-501. doi: 10.1001/jamaophthalmol.2013.5841. PMID: 24557359.
Melles GR, Binder PS. A comparison of wound healing in sutured and unsutured corneal wounds. Arch Ophthalmol. 1990 Oct;108(10):1460-9. doi: 10.1001/archopht.1990.01070120108039. PMID: 2222279.
Melles GR, Binder PS, Anderson JA. Variation in healing throughout the depth of long-term, unsutured, corneal wounds in human autopsy specimens and monkeys. Arch Ophthalmol. 1994 Jan;112(1):100-9. doi: 10.1001/archopht.1994.01090130110027. PMID: 8285876.
Alió JL, Shabayek MH. Corneal higher order aberrations: a method to grade keratoconus. J Refract Surg. 2006 Jun;22(6):539-45. doi: 10.3928/1081-597X-20060601-05. PMID: 16805116.
Koh S, Maeda N, Nakagawa T, Nishida K. Quality of vision in eyes after selective lamellar keratoplasty. Cornea. 2012 Nov;31 Suppl 1:S45-9. doi: 10.1097/ICO.0b013e318269c9cd. PMID: 23038035.
Oculus Optikgeräte GmbH. Oculus Pentacam instruction manual: measurement and evaluation system for the anterior segment of the eye. Wetzlar, Germany: Oculus Optikgeräte GmbH; 2005.
van Dijk K, Parker J, Tong CM, Ham L, Lie JT, Groeneveld-van Beek EA, Melles GR. Midstromal isolated Bowman layer graft for reduction of advanced keratoconus: a technique to postpone penetrating or deep anterior lamellar keratoplasty. JAMA Ophthalmol. 2014 Apr 1;132(4):495-501. doi: 10.1001/jamaophthalmol.2013.5841. PMID: 24557359.
Lie J, Droutsas K, Ham L, Dapena I, Ververs B, Otten H, van der Wees J, Melles GR. Isolated Bowman layer transplantation to manage persistent subepithelial haze after excimer laser surface ablation. J Cataract Refract Surg. 2010 Jun;36(6):1036-41. doi: 10.1016/j.jcrs.2010.03.032. PMID: 20494779.
Sawaguchi S, Fukuchi T, Abe H, Kaiya T, Sugar J, Yue BY. Three-dimensional scanning electron microscopic study of keratoconus corneas. Arch Ophthalmol. 1998 Jan;116(1):62-8. doi: 10.1001/archopht.116.1.62. PMID: 9445209.
Gipson IK, Joyce NC, Zieske JD. The anatomy and cell biology of the human cornea, limbus, conjunctiva and adnexa. In: Foster CS, Azar D, Dolhman CH, eds, The Cornea. Philadelphia, PA, Lippincott, Williams & Wilkins, 2004; 1–35.
Germundsson J, Karanis G, Fagerholm P, Lagali N. Age-related thinning of Bowman's layer in the human cornea in vivo. Invest Ophthalmol Vis Sci. 2013 Sep 11;54(9):6143-9. doi: 10.1167/iovs.13-12535. PMID: 23970471.
Tuori AJ, Virtanen I, Aine E, Kalluri R, Miner JH, Uusitalo HM. The immunohistochemical composition of corneal basement membrane in keratoconus. Curr Eye Res. 1997 Aug;16(8):792-801. doi: 10.1076/ceyr.16.8.792.8989. PMID: 9255508.
Sawaguchi S, Fukuchi T, Abe H, Kaiya T, Sugar J, Yue BY. Three-dimensional scanning electron microscopic study of keratoconus corneas. Arch Ophthalmol. 1998 Jan;116(1):62-8. doi: 10.1001/archopht.116.1.62. PMID: 9445209.
Boote C, Du Y, Morgan S, Harris J, Kamma-Lorger CS, Hayes S, Lathrop KL, Roh DS, Burrow MK, Hiller J, Terrill NJ, Funderburgh JL, Meek KM. Quantitative assessment of ultrastructure and light scatter in mouse corneal debridement wounds. Invest Ophthalmol Vis Sci. 2012 May 14;53(6):2786-95. doi: 10.1167/iovs.11-9305. PMID: 22467580; PMCID: PMC3367468.
Grieve K, Georgeon C, Andreiuolo F, Borderie M, Ghoubay D, Rault J, Borderie VM. Imaging Microscopic Features of Keratoconic Corneal Morphology. Cornea. 2016 Dec;35(12):1621-1630. doi: 10.1097/ICO.0000000000000979. PMID: 27560027; PMCID: PMC5094201.
van Dijk K, Parker J, Tong CM, Ham L, Lie JT, Groeneveld-van Beek EA, Melles GR. Midstromal isolated Bowman layer graft for reduction of advanced keratoconus: a technique to postpone penetrating or deep anterior lamellar keratoplasty. JAMA Ophthalmol. 2014 Apr 1;132(4):495-501. doi: 10.1001/jamaophthalmol.2013.5841. PMID: 24557359.
van Dijk K, Parker JS, Baydoun L, Ilyas A, Dapena I, Groeneveld-van Beek EA, Melles GRJ. Bowman layer transplantation: 5-year results. Graefes Arch Clin Exp Ophthalmol. 2018 Jun;256(6):1151-1158. doi: 10.1007/s00417-018-3927-7. Epub 2018 Feb 14. PMID: 29445872.
Groeneveld-van Beek EA, Parker J, Lie JT, Bourgonje V, Ham L, van Dijk K, van der Wees J, Melles GR. Donor Tissue Preparation for Bowman Layer Transplantation. Cornea. 2016 Dec;35(12):1499-1502. doi: 10.1097/ICO.0000000000000905. PMID: 27362885.
van Dijk K, Liarakos VS, Parker J, Ham L, Lie JT, Groeneveld-van Beek EA, Melles GR. Bowman layer transplantation to reduce and stabilize progressive, advanced keratoconus. Ophthalmology. 2015 May;122(5):909-17. doi: 10.1016/j.ophtha.2014.12.005. Epub 2015 Jan 14. PMID: 25596620.
Aristeidou A, Taniguchi EV, Tsatsos M, Muller R, McAlinden C, Pineda R, Paschalis EI. The evolution of corneal and refractive surgery with the femtosecond laser. Eye Vis (Lond). 2015 Jul 14;2:12. doi: 10.1186/s40662-015-0022-6. PMID: 26605365; PMCID: PMC4655461.
Ibrahim T, Goernert P, Rocha G. Femto-second laser (FSL) techniques and consistency in corneal surgery: experimental study. Can J Ophthalmol. 2018 Aug;53(4):324-329. doi: 10.1016/j.jcjo.2017.11.005. Epub 2018 Apr 2. PMID: 30119784.
Grewal DS, Schultz T, Basti S, Dick HB. Femtosecond laser-assisted cataract surgery--current status and future directions. Surv Ophthalmol. 2016 Mar-Apr;61(2):103-31. doi: 10.1016/j.survophthal.2015.09.002. Epub 2015 Sep 26. PMID: 26409902.
Aristeidou A, Taniguchi EV, Tsatsos M, Muller R, McAlinden C, Pineda R, Paschalis EI. The evolution of corneal and refractive surgery with the femtosecond laser. Eye Vis (Lond). 2015 Jul 14;2:12. doi: 10.1186/s40662-015-0022-6. PMID: 26605365; PMCID: PMC4655461.
Pajic B, Vastardis I, Pajic-Eggspuehler B, Gatzioufas Z, Hafezi F. Femtosecond laser versus mechanical microkeratome-assisted flap creation for LASIK: a prospective, randomized, paired-eye study. Clin Ophthalmol. 2014 Sep 22;8:1883-9. doi: 10.2147/OPTH.S68124. PMID: 25284975; PMCID: PMC4181739.
Moshirfar M, Gardiner JP, Schliesser JA, Espandar L, Feiz V, Mifflin MD, Chang JC. Laser in situ keratomileusis flap complications using mechanical microkeratome versus femtosecond laser: retrospective comparison. J Cataract Refract Surg. 2010 Nov;36(11):1925-33. doi: 10.1016/j.jcrs.2010.05.027. PMID: 21029902.
Galvis V, Tello A, Carreño NI, Berrospi RD, Niño CA, Leiva F. Keratoconus and Bowman Layer Transplantation. Cornea. 2017 Mar;36(3):e8. doi: 10.1097/ICO.0000000000001142. PMID: 28079692.
Lu Y, Shi YH, Yang LP, Ge YR, Chen XF, Wu Y, Huang ZP. Femtosecond laser-assisted deep anterior lamellar keratoplasty for keratoconus and keratectasia. Int J Ophthalmol. 2014 Aug 18;7(4):638-43. doi: 10.3980/j.issn.2222-3959.2014.04.09. PMID: 25161934; PMCID: PMC4137198.
Jabbarvand M, Salamatrad A, Hashemian H, Mazloumi M, Khodaparast M. Continuous intracorneal ring implantation for keratoconus using a femtosecond laser. J Cataract Refract Surg. 2013 Jul;39(7):1081-7. doi: 10.1016/j.jcrs.2013.02.054. Epub 2013 May 22. PMID: 23706931.
Groeneveld-van Beek EA, Parker J, Lie JT, Bourgonje V, Ham L, van Dijk K, van der Wees J, Melles GR. Donor Tissue Preparation for Bowman Layer Transplantation. Cornea. 2016 Dec;35(12):1499-1502. doi: 10.1097/ICO.0000000000000905. PMID: 27362885.
Zaman Shah*, Ibrar Hussain, Sanaullah Jan, P S Mahar, Mazhar Ishaq and Fawad RizviZaman Shah*,Ibrar Hussain,Sanaullah Jan,P S Mahar,Mazhar Ishaq,Fawad Rizvi. Treatment of advance keratoconus using donor bowman layer: the zaman technique of bowman layer transplantation (Type I & Type II). . 2022 doi: 10.29328/journal.ijceo.1001045; 6: 015-025
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H Pérez-Aguilar*, M Lacruz-Asaro and F Arán-AisH Pérez-Aguilar*, M Lacruz-Asaro, F Arán-Ais. Evaluation of Biostimulants Based on Recovered Protein Hydrolysates from Animal By-products as Plant Growth Enhancers. J Plant Sci Phytopathol. 2023 doi: 10.29328/journal.jpsp.1001104; 7: 042-047
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Julian A Purrinos* and Ramzi YounisJulian A Purrinos*, Ramzi Younis. Sinonasal Myxoma Extending into the Orbit in a 4-Year Old: A Case Presentation. Arch Case Rep. 2024 doi: 10.29328/journal.acr.1001099; 8: 075-077
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