Abstract

Research Article

Comparative Analysis of Demographic and Clinical Profiles of Conventional Retinopathy of Prematurity with Aggressive Posterior Retinopathy of Prematurity

Sakshi Lochab*, Manisha Mada, Ritesh Verma and Jitender Phogat

Published: 10 September, 2024 | Volume 8 - Issue 2 | Pages: 016-020

Aim: To compare the demographic and clinical profile of conventional retinopathy of prematurity (ROP) with aggressive posterior retinopathy of prematurity.
Material and methods: A prospective, unmasked, and observational study involving 150 ROP patients was conducted over a period of one year. The risk factors including maternal and neonatal risk factors were recorded. The data was entered into the Excel sheet and analyzed to compare the risk factors between the conventional ROP and APROP.
Results: A total of 17 (11.3%) babies were found to have AP-ROP and 133 (88.7%) babies were found to have conventional ROP. There was no significant difference in average gestational age between infants diagnosed with AP-ROP (29.6 ± 2.9 weeks) and those with Conventional ROP (30.1 ± 2.2 weeks) (p = 0.428). However, infants with AP-ROP had a significantly lower average birth weight (1022.7 ± 123.5 g) compared to infants with Conventional ROP (1208.2 ± 261.0 g) (p  = 0.004). Multivariate logistic regression analysis revealed that birth weight, surfactant use, number of days of oxygen supplementation, and metabolic acidosis were independently associated with the development of AP-ROP.
Conclusion: The development of APROP is multifactorial and complex. Although we have identified factors such as birth weight, surfactant use, number of days of oxygen supplementation, and metabolic acidosis in the causation of APROP, further long-term multicentric studies are required for validation.

Read Full Article HTML DOI: 10.29328/journal.ijceo.1001057 Cite this Article Read Full Article PDF

References

  1. Bashinsky AL. Retinopathy of prematurity. N C Med J. 2017;78(2):124-128. Available from: https://doi.org/10.18043/ncm.78.2.124
  2. Hellström A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet. 2013;382(9902):1445-1457. Available from: https://doi.org/10.1016/s0140-6736(13)60178-6
  3. Campbell K. Intensive oxygen therapy as a possible cause of retrolental fibroplasia: a clinical approach. Med J Aust. 1951;2(2):48-50. Available from: https://pubmed.ncbi.nlm.nih.gov/14874698/
  4. Seiberth V, Linderkamp O. Risk factors in retinopathy of prematurity. Ophthalmologica. 2000;214(2):131-135. Available from: https://doi.org/10.1159/000027482
  5. Purohit DM, Ellison RC, Zierler S, Miettinen OS, Nadas AS. Risk factors for retrolental fibroplasia: experience with 3,025 premature infants. Pediatrics. 1985;76(3):339-344. Available from: https://pubmed.ncbi.nlm.nih.gov/2863804/
  6. Gilbert C. Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control. Early Hum Dev. 2008;84(2):77-82. Available from: https://doi.org/10.1016/j.earlhumdev.2007.11.009
  7. Holmström G, Thomassen P, Broberger U. Maternal risk factors for retinopathy of prematurity–a population‐based study. Acta Obstet Gynecol Scand. 1996;75(7):628-635. Available from: https://doi.org/10.3109/00016349609054687
  8. Hammer ME, Mullen PW, Ferguson JG, Pai S, Cosby C, Jackson KL. Logistic analysis of risk factors in acute retinopathy of prematurity. Am J Ophthalmol. 1986;102(1):1-6. Available from: https://doi.org/10.1016/0002-9394(86)90200-x
  9. Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity. N Engl J Med. 2012;367(26):2515-2526. Available from: https://doi.org/10.1056/nejmra1208129
  10. International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol. 2005 Jul;123(7):991-999. Available from: https://doi.org/10.1001/archopht.123.7.991
  11. Chiang MF, Quinn GE, Fielder AR, Ostmo SR, Chan RP, Berrocal A, et al. International classification of retinopathy of prematurity. Ophthalmology. 2021;128(10):e51-68. Available from: https://doi.org/10.1016/j.ophtha.2021.05.031
  12. Sanghi G, Sawhney JS, Kaur S, Kumar N. Evaluation of clinical profile and screening guidelines of retinopathy of prematurity in an urban level III neonatal intensive care unit. Indian J Ophthalmol. 2022;70(7):2476-2479. Available from: https://doi.org/10.4103/ijo.ijo_1925_21
  13. Rashtriya Bal Swasthya Karyakram, Ministry of Health &Family Welfare, Government of India Guidelines for Universal Eye Screening in Newborns including Retinopathy of Prematurity June 2017 available at Available from: https://www.nhm.gov.in/images/pdf/programmes/RBSK/Resource_Documents/Revised_ROP_Guidelines-Web_Optimized.pdf
  14. Vinekar A, Jayadev C, Mangalesh S, Shetty B, Vidyasagar D. Role of Tele-Medicine in retinopathy of prematurity screening in rural Outreach Centers in India – a report of 20,214 imaging sessions in the KIDROP program. Seminars in Fetal and Neonatal Medicine. 2015;20(5):335-345. Available from: https://doi.org/10.1016/j.siny.2015.05.002
  15. Sathar A, Shanavas A, Jasmin LB, Girija Devi PS. Outcome of Aggressive Posterior Retinopathy of Prematurity in a Tertiary Care Hospital in South India. J Med Sci Clin Res. 2017;5(4):20885-20891. Available from: https://dx.doi.org/10.18535/jmscr/v5i4.182
  16. Ahn YJ, Hong KE, Yum HR, Lee JH, Kim KS, Youn YA, et al. Characteristic clinical features associated with aggressive posterior retinopathy of prematurity. Eye (Lond). 2017 Jun;31(6):924-930. Available from: https://doi.org/10.1038/eye.2017.18
  17. Bastola P, Parchand SM, Gangwe AB, Bastola S, Agrawal D. Retinopathy of Prematurity among Preterm Newborn Admitted to the Neonatal Care Unit in a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2023;61(260):329-333. Available from: https://doi.org/10.31729/jnma.8117
  18. Dwivedi A, Dwivedi D, Lakhtakia S, Chalisgaonkar C, Jain S. Prevalence, risk factors and pattern of severe retinopathy of prematurity in eastern Madhya Pradesh. Indian J Ophthalmol. 2019;67(6):819-823. Available from: https://doi.org/10.4103/ijo.ijo_1789_18
  19. Tekchandani U, Katoch D, Dogra MR. Five-year demographic profile of retinopathy of prematurity at a tertiary care institute in North India. Indian J Ophthalmol. 2021;69(8):2127-2131. Available from: https://doi.org/10.4103/ijo.ijo_132_21
  20. Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singap. 2005;34(2):169-178. Available from: https://pubmed.ncbi.nlm.nih.gov/15827664/
  21. Thomas K, Shah PS, Canning R, Harrison A, Lee SK, Dow KE. Retinopathy of prematurity: risk factors and variability in Canadian neonatal intensive care units. J Neonatal Perinatal Med. 2015;8(3):207-214. Available from: https://doi.org/10.3233/npm-15814128
  22. Hakeem AH, Mohamed GB, Othman MF. Retinopathy of prematurity: a study of prevalence and risk factors. Middle East Afr J Ophthalmol. 2012 Jul;19(3):289-294. Available from: https://doi.org/10.4103/0974-9233.97927
  23. Nayyar M, Sood M, Panwar PK. Profile and risk factors of sight-threatening retinopathy of prematurity: Experience from SNCU in North India. Oman J Ophthalmol. 2024;17(2):224-233. Available from: https://doi.org/10.4103/ojo.ojo_167_23
  24. Retinopathy of prematurity: a review of risk factors and their clinical significance. Kim SJ, Port AD, Swan R, Campbell JP, Chan RV, Chiang MF. Surv Ophthalmol. 2018;63:618-637. Available from: https://doi.org/10.1016/j.survophthal.2018.04.002
  25. Dhull V, Phogat J, Agrawal A, Singh S, Gathwala G, Nada M, et al. Retinopathy of Prematurity: Analysis of Demographic and Clinical Profiles, Incidence, Risk Factors and Treatment Outcome. Saudi J Med Pharm Sci. 2019;5(7):626-636. Available from: https://saudijournals.com/media/articles/SJMPS_57_626-636_c.pdf

Figures:

Similar Articles

Recently Viewed

  • Environmental Factors Affecting the Concentration of DNA in Blood and Saliva Stains: A Review
    Divya Khorwal*, GK Mathur, Umema Ahmed and SS Daga Divya Khorwal*, GK Mathur, Umema Ahmed, SS Daga. Environmental Factors Affecting the Concentration of DNA in Blood and Saliva Stains: A Review. J Forensic Sci Res. 2024: doi: 10.29328/journal.jfsr.1001057; 8: 009-015
  • Why Down-managing Backlog Forensic DNA Case Entries Matters
    JH Smith* and JS Horne JH Smith*, JS Horne. Why Down-managing Backlog Forensic DNA Case Entries Matters. J Forensic Sci Res. 2024: doi: 10.29328/journal.jfsr.1001056; 8: 001-008
  • Scintigraphic non-invasive diagnosis of amyloid cardiomyopathy
    Laroussi Mohamed-Salem*, Tomás E Rodríguez-Locarno, Tatiana Moreno-Monsalve, Isabel Castellón-Sánchez, José F Contreras-Gutiérrez and Antonia Claver-Valderas Laroussi Mohamed-Salem*,Tomás E Rodríguez-Locarno,Tatiana Moreno-Monsalve,Isabel Castellón-Sánchez,José F Contreras-Gutiérrez ,Antonia Claver-Valderas. Scintigraphic non-invasive diagnosis of amyloid cardiomyopathy. J Cardiol Cardiovasc Med. 2019: doi: 10.29328/journal.jccm.1001058; 4: 156-158
  • Anomalies of coronary artery origin: About two cases
    Dioum M*, Sarr EM, Manga S, Mingou JS, Diack A, Diop AD, Bindia D, Diagne PA, Sarr AN and Diop IB Dioum M*,Sarr EM,Manga S,Mingou JS,Diack A,Diop AD,Bindia D,Diagne PA,Sarr AN,Diop IB. Anomalies of coronary artery origin: About two cases. J Cardiol Cardiovasc Med. 2019: doi: 10.29328/journal.jccm.1001051; 4: 117-119
  • Late discover of a traumatic cardiac injury: Case report
    Benlafqih C, Bouhdadi H*, Bakkali A, Rhissassi J, Sayah R and Laaroussi M Benlafqih C,Bouhdadi H*,Bakkali A,Rhissassi J,Sayah R,Laaroussi M. Late discover of a traumatic cardiac injury: Case report. J Cardiol Cardiovasc Med. 2019: doi: 10.29328/journal.jccm.1001048; 4: 100-102

Read More

Most Viewed

Read More

Help ?